Hand me downs syndrome

1) When a younger sibling feels entitled to everything their elder sibling owns.

1)Agh! My little sister stole my new Mac lipstick again! She's got total hand me downs syndrome!

by Ulessa April 20, 2017

Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 1, 2021

Down Syndrome

Also known as Trisomy 21. With 23 pairs of chromosomes, a person with Down Syndrome (i.e., a retard) has an extra 21st chromosome, causing several physical and mental defects. Usually easily recognized due to the retarded shape of their face and the clueless, happy expression on their face. These poor brain-dead sacks of sweaty garbage might be able to hold down a job as a greeter at Walmart, but this is about as high up the corporate ladder that these circus freaks typically go.

"Oh my god, did you see that dipshit window-licker trying to parallel park a shopping cart? What a down syndrome, fat fucking gay retard, fucking just dumbass stupid fucking loser. Let's kill him. I'll drown his ass, what a fucking puke piece of shit."

by Jack-the-stripper-ripper May 2, 2025

Down Syndrome Ass

A large and disproportionate butt

Yo Trayvon, have you seen Lynteria's ass lately. That girl is walking around with a down syndrome ass without even knowing it.

by White Boi Brain January 16, 2024

Down syndrome

A retarted ass dog named duke that has 3 missing chromosomes and likes dick up his ass and having cats shoved up his ass

Person 1 : how’s down syndrome

Person 2 : he’s not Down syndrome it’s fucking duke

by Retartedmonkey August 16, 2023

Down syndrome pedro

A Snitch who tells a guy/Usually his brother about jerking off in a forest

You Bro You hear that guy is a down syndrome pedro No way bro

by Canadian beastiality June 27, 2020

Down Syndrome Ass

A large and disproportionate butt

Yo Trayvon, have you seen Taylor's ass lately. That girl is walking around with a down syndrome ass without even knowing it.

by White Boi Brain January 16, 2024