Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 1, 2021

down river syndrome

When a person has chromosomal damage from living down river near Detroit

Man that guy has a bad case of down river syndrome

by Kauai-kimo September 23, 2022

Down syndromic

Just another way to call someone with Down syndrome

Look at that retard he’s so down syndromic

by Sellout President September 5, 2023

Down Syndrome Ass

A large and disproportionate butt

Yo Trayvon, have you seen Taylor's ass lately. That girl is walking around with a down syndrome ass without even knowing it.

by White Boi Brain January 16, 2024

down syndrome nigel

the retarded kid at in class who always had snot running into his mouth

down syndrome nigel breaks stupidity world record

by mrs tosser August 6, 2025

Down syndrome pedro

A Snitch who tells a guy/Usually his brother about jerking off in a forest

You Bro You hear that guy is a down syndrome pedro No way bro

by Canadian beastiality June 27, 2020

down syndrome

cody zinkus down syndrome

cody zinkus looks like a sped down syndrome

by bubblebath280 December 20, 2023