Hackney Downs Syndrome

Condition where someone moves to Hackney, grows stupid facial hair, starts wearing braces and woolly hats and riding a fixie retro bicycle, turns Vegan suddenly and decorates their home with overpriced unwanted furniture and recycled pallets. Even buys a turntable.

Since Colin moved to Dalston, he’s turned into a right wanker. That guys got a serious case of Hackney Downs Syndrome.

by Blah wars September 30, 2018

Down syndrome

Lukas ;)

Lukas has Down syndrome

by Urlocalnugget August 15, 2020

Down Syndrome

Also known as Trisomy 21. With 23 pairs of chromosomes, a person with Down Syndrome (i.e., a retard) has an extra 21st chromosome, causing several physical and mental defects. Usually easily recognized due to the retarded shape of their face and the clueless, happy expression on their face. These poor brain-dead sacks of sweaty garbage might be able to hold down a job as a greeter at Walmart, but this is about as high up the corporate ladder that these circus freaks typically go.

"Oh my god, did you see that dipshit window-licker trying to parallel park a shopping cart? What a down syndrome, fat fucking gay retard, fucking just dumbass stupid fucking loser. Let's kill him. I'll drown his ass, what a fucking puke piece of shit."

by Jack-the-stripper-ripper May 2, 2025

Down syndromic

Just another way to call someone with Down syndrome

Look at that retard he’s so down syndromic

by Sellout President September 5, 2023

Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 1, 2021

down river syndrome

When a person has chromosomal damage from living down river near Detroit

Man that guy has a bad case of down river syndrome

by Kauai-kimo September 23, 2022

dj down syndrome

Samsquatch, jef

My name is DJ down syndrome but you can call me Jef

by DJ DOWNSYNDROME November 20, 2017