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pneumonoultramicroscopicsilicovolcanoconiosis 

A ling disease. Means you can't speak.
pneumonoultramicroscopicsilicovolcanoconiosis means you can't speak. Also, it means that this word is the longest word in the dictionary.

pneumonoultramicroscopicsilicovolcanoconiosis 

This is the longest word in the English language.
It is a lunge disease caused by breathing in the ashes of a volcano
Doctor: you have pneumonoultramicroscopicsilicovolcanoconiosis
Patient: say what now?
Doctor: pneumonoultramicroscopicsilicovolcanoconiosis
Patient: oh no, I’m gonna die before I learn how to even say that

Pneumonoultramicroscopicsilicovolcanoconiosis 

For when you want to flex your knowledge to friends

(It's actually a disease)
Me: I know the longest word in the English language

Friend: say it

Me: Pneumonoultramicroscopicsilicovolcanoconiosis

Friend: :O

pneumonoultramicroscopicsilicovolcanoconiosis 

A disease caused by inhaling fine ash or sand. This word wasn't invented long ago.
This person have pneumonoultramicroscopicsilicovolcanoconiosis due to inhaling ash.

pneumonoultramicroscopicsilicovolcanoconiosis 

its a cancer, stage 4 cancer but not really mate it is indeed lung disease but not that cancerish~
john:hey was good
nathan:ye
john:lets play the "give me longest word you got"
nathan:ok
john:me first then pneumonoultramicroscopicsilicovolcanoconiosis
nathan: you're retarded fucker

pneumonoultramicroscopicsilicovolcanoconiosis 

An invented long word said to mean a lung disease caused by inhaling very fine ash and sand dust, coming from 1930s: a word invented (probably by Everett M. Smith, president of the National Puzzlers' League) in imitation of very long medical terms.
Friend: Hey man, the doctor said that I have pneumonoultramicroscopicsilicovolcanoconiosis. I might die.
Me: What?
Friend: I said that I have pneumonoultramicroscopicsilicovolcanoconiosis.
Me:wHAt?