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Originating from being remarkably high off of Xanax or Zannys to the point where your brain almost shuts down.

Now in drug culture it is used in general in reference to being high.
He or she isn’t high, they’re zooted. In other words, completely gone off this earth.
Zooted by TheSavageAaron August 23, 2020
NYC original slang for being super high or super Bent or both !
Ya boy zooted out his mind! Facts B! Homeboy really zooted out here!
Zooted by Zooted Daily September 8, 2020
When someone is so loving to their parents.
Christian is a very nice kid, he is zooted.
Zooted by fartalotmcqueen September 27, 2020
When someone is sleep or drunk or high
Dude look at that girl over there she can barely stand up she must be zooted
Zooted by Jon brannn November 11, 2020
This adjective is a variation of the word “booted” which means very high or drunk; fucked up.

However the addition of the “Z” to replace “B” signifies a specific type of high caused by sedative, prescription medications.

The Z’s you catch from sleeping and certain names of said medications pair together well in linguistic terms— “xanned out,” “zooted off them xannies”
My mans is zooted off them xans..
Zooted by JaycAker October 31, 2020
To die, or to smoke marijuana to the point of near death
“I got sooo Zooted at Andy’s kickback
Zooted by Johnny Silverhand February 16, 2021