Down syndrome 

Another name for opiate junkies who are nodding out on the shit. Often so retarded/out of it that they manage to light themselves on fire smoking heroin off of tin foil, or when they fall asleep smoking.

Dude 1: "Hey, what's wrong with that guy over there? He's sleeping and drooling all over himself, and his cigarette is so close to that pile of flammable magazines..."
Dude 2: "Oh, that's just Derek. He's got Down syndrome. Every time he gets paid he buys oxycontins."

Down syndrome by westernclassics October 14, 2009

down syndrome 

A phrase used to make fun of someone after they have done something stupid. Also, a disease similar to mental retardation. Many people who have down syndrome have competed in the Special Olympics.

What the hell is your problem! Are you down syndrome or something?

down syndrome by J-dog April 9, 2005

down syndrome 

very strange...and exessively weird

cara is the coolest kid with down syndrome i know

down syndrome by ilovematthew May 17, 2006

Down Syndrome 

People who have extra chromosomes. Often make jokes that make no sense and have to explain and despite that, the joke still makes no sense. Symptoms are using out of context memes, reselling and having sexual temptations of animals

Saajan has down syndrome

Down Syndrome by Immigrant_Kid March 29, 2020

down syndrome 

an insult, to say to ones friends when they are acting 'crippled'

Clutch, are you fuckin down syndrome!

down syndrome by 106_joN March 27, 2005

Down Syndrome 

Many people think that people with Down Syndrome are stupid and look weird. I think the opposite, they are strong and independent and loving and smart people. Their so awesome that everyone should be their friend.

Remember a little kindness cam go a long way.

People With Down Syndrome are Awesome People!

Down Syndrome by #LBMF October 3, 2019

thumbs down syndrome 

thumbs down syndrome is a sickness were stupid people like to thumbs down anything and everything if they dont like what they see or read usually a response to internet videos or comments like on youtube that they dont like just to try and prove a point

bob damn bill im not feelin so good i think after readin that latest comment im coming down with thumbs down syndrome it makes me wanna go and lowrate everything that i disagree with maybe that will make me feel better about myself

thumbs down syndrome by ODog N Cali M.C N T May 16, 2011