Tweak

To not relax; to not chill; to mimic someone suffering from a unique combination of schizophrenia and terets, presenting a lack of logical thought upon speaking.
Don't tweak bro, relax.

I'm chill man, I never tweak on acid.

Relax for a second, or you might start to tweak.
by TweakOrBust December 04, 2017
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tweak

While running they tweaked their hamstring.
by Kelpy deery February 04, 2021
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Tweak

A guy who talks shit behind peoples back but is coward in front of the person and is too fat to be called a Twink. He makes fun of and points out insecurities and he’s more insecure of himself. Victimizes himself because he’s a wimp to say that he’s wrong. He is an instigator and causes problems that aren’t that big of a deal. He also be taking jokes way too far and gets mad when you call him out and has the ugliest perm and wears emo earrings.
Armani you fucking Tweak.”

“You Tweak ass is so annoying go somewhere else you bitch.”

“Fuck you Tweak motherfucker pussy ass bitch
by Beomtori September 21, 2023
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Tweak

TWEAK is a word often used to describe the illegal narcotic " crystal meth " also known as methamphetamine.

You: "Well why do we refer to meth as tweak anyway?"
Professor Pookie: Great question young smoker. I will tell you the origin and reason, listen carefully.

Long ago, many years ago crystal meth had just had become well known for being a white trash drug (commonly referred as "poor mans cocaine") and back then the drug was made with a key ingredient ephedrine which was later on banned in the U.S.A by the FDA in 2003. Long before it was banned, it was really purest dope you could get.
A man who apparently had never done the potent drug before in his life, decided to try it for the first time. In conclusion the man was wide awake, unable to sleep, eat, or sit down still. The meth was so strong at that time, that when you would talk you would speak way too fast.

Legend is that the man was asked how long he had been up for and in response the man answered in a very fast

tasmanian devil type of voice and said "TWOWEEKS, I BE UP TWOWEEKS NOW" and in conclusion it sounded like the man was saying "TWEAK" and from that point on it was associated with crystal meth.
"TWOWEEKS, I BE UP TWOWEEKS NOW" is the sentence that a man who had been high for two whole weeks said and made a compound "Tweak" be associated to the drug "crystal methamphetamine .
by DJ Literally Lit January 01, 2019
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Tweak

when you have a freak out .

When you go ape shit.
I'm gonna tweak the fuck out!

Bro, that kid fucked with me and i tweaked on him!
by pegasus12344 December 26, 2018
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Tweaked

“Yo he tweaked out 4 rlly

“Damn vro
by aceless666 August 12, 2023
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tweaking

when someone is acting a weird type of way for no reason at all.
Yo, why is you tweaking? I didn’t steal your shit.
by lilshitstain January 16, 2019
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