Duff 

Designated Ugly Fat Friend.

Its one person in a group who makes everyone else in the group look better. The duff doesnt have to be ugly or fat.

Hannah is clearly the duff of the group!

Duff by Shortneyyy😛✌🏻️ June 15, 2015

duff 

To catch a fart in your hand and put in someones face. A duff is similar to a fast ball, however it is not thrown.

Can I duff you?" "Yeah, duff me! Gimme yer duff!

duff by Andrea, St. Petersburg, FL September 11, 2010

duff 

Generic term for beer. Originates from The Simpsons cartoon series, where Duff is the brand of beer characters drink.

"Pass me that duff". "You bring the weed and I'll bring the duff!"

duff by Karl Steiger January 31, 2004

duff 

the residual left in the bag of narcotics; the powder.

Dude... Where's all the rocks? That's just a bag of duff!

duff by sophuct72 February 5, 2010

DUFF 

Designated ugly fat fuck

Aye that bitch is a duff

DUFF by bigfloppykitty February 9, 2015

Duff 

Duff is an acronym meaning Dumb Ugly Fat Friend or Designated Ugly Fat Friend.

Generally a cockblocker and a bitch, have a desperate friend take her down.

Friend 1: Dude I want to hook up with that girl, but her duff is in my way.

Friend 2: It may be Amber but i'll take the duff down.

Duff by Jap Anus Relations July 29, 2009

DUFF 

Designated Ugly Fat Friend

Wow, who brought the Duff to the party!?!? Not cool guys...

DUFF by DUFF HUNTER August 15, 2009