Duff

Designated Ugly Fat Friend.

Its one person in a group who makes everyone else in the group look better. The duff doesnt have to be ugly or fat.

Hannah is clearly the duff of the group!

by Shortneyyy😛✌🏻️ June 15, 2015

duff

To catch a fart in your hand and put in someones face. A duff is similar to a fast ball, however it is not thrown.

Can I duff you?" "Yeah, duff me! Gimme yer duff!

by Andrea, St. Petersburg, FL September 11, 2010

duff

Generic term for beer. Originates from The Simpsons cartoon series, where Duff is the brand of beer characters drink.

"Pass me that duff". "You bring the weed and I'll bring the duff!"

by Karl Steiger January 31, 2004

duff

the residual left in the bag of narcotics; the powder.

Dude... Where's all the rocks? That's just a bag of duff!

by sophuct72 February 5, 2010

DUFF

Designated ugly fat fuck

Aye that bitch is a duff

by bigfloppykitty February 9, 2015

Duff

Duff is an acronym meaning Dumb Ugly Fat Friend or Designated Ugly Fat Friend.

Generally a cockblocker and a bitch, have a desperate friend take her down.

Friend 1: Dude I want to hook up with that girl, but her duff is in my way.

Friend 2: It may be Amber but i'll take the duff down.

by Jap Anus Relations July 29, 2009

DUFF

Designated Ugly Fat Friend

Wow, who brought the Duff to the party!?!? Not cool guys...

by DUFF HUNTER August 15, 2009