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up in this bitch 

another way of saying "up in here." Only it's a way better way of saying it because peoples know you mean bizness cuz of the expletive.
Damn dude, I gots the munchies. We need some brownies up in this bitch.

Up in this Ma' 

Short for "Up in this MotherFucker"

Too be "apart of" or "in this general location, of"

up in this motherfucker 

Dope phrase you can put at the end of any sentence.
'Bout to tear it up, up in this motherfucker.
I think the hos are bomb up in this motherfucker.

I put my beer down and got down with her, up in this motherfucker.

up in this bitch 

meaning "up in here" but with swearing to emphasise the point.
"let's get some beer up in this bitch"
"this funeral is really sad, someone get some tissues up in this bitch"
"let's get this thermometer up in this bitch"
up in this bitch by Gnaruto August 10, 2016

up in this joint

Girl 1: Omg, Huaraches are sooooo up in this joint!
Girl 2: Ikr, so true!! I finna go buy some right now!

up in this A 

A= air.

if you're a baller then you're up in the a.

or... its like where you are. ya know... up in this a?
I'm a baller up in the A.
It smells like a dog up in this a.
up in this A by pseudonym00000001 November 15, 2009