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Holy mother 

Person 1: holy mother!
Person 2: what?
Person 1: that shit scared me so bad!

Holy Mother Forking Shirt balls

The good place season 1 episode 11, when Elanor realises its not the good place
Holy Mother Forking Shirt balls, you guys were being tortured

Holy Mother Mackerel 

Holy Mother of Pearl 

this saying has its origins in the 70s love movement and was made really famous by Cheech & Chong in the 80s through their marijuanha films.

It does not mean OMG or awesome. It's a stand-alone phrase, usually preceding the phrase that will describe the object or situation that's freaking you out, blowing you away or leaving you at a loss for words.

It's present tense, denoting something that's actually happening and feels like it is beyond incredible.
Holy mother of pearl! Look at those tender young asses(on the beach);- cops in helicopter shadowing Cheech & Chong.

Holy mother of pearl! That's some serious shit.

Holy mother of pearl! That's one strong fuckin drink.

Holy mother of pearl! Did you see that?(a flying dog playing a guitar and shooting laserbeams from its eyes)

A spaceship appearing over London would leave you speechless, probably only with the ability to utter the words 'holy mother of pearl.'

Holy mother of hell 

(Walking through the halls of a very crowded school where freshmen feel it's okay to stand in the middle of the hall and make out)

"Holy mother of hell! Move it and get a room!"
Holy mother of hell by KayKaboom October 1, 2009

holy mother of burnt croissants 

Holy Mother of Burnt Croissants! I almost got sniped.