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A lame spelling of the common "wuddup." However, it is not used as a greeting in most cases. It is commonly used as in introduction on meaningless facebook updates in times of distress when the user wants to appear cool or hip in nature, usually to much failure and pity.
Jim: "Whuddup new shoes!"
Carl: "wow...what do I even say to this?"
Whuddup by milkmanmaxxie February 26, 2011
conjunction of the phrase, "what is up?"
whaddup by ill bill December 23, 2002

Whaddup doe

another way of saying what's up, typically used in the Detroit area.
Hey, when you see him, tell him I said "Whaddup doe!"
Whaddup doe by wildfire98 April 6, 2010
What people with immense amounts of swagger say when greeting people.
Guy: Whaddup

Girl: Oh my god he's got so much swagger *melts*

Whaddupdoe? 

Whaddupdoe- interj. v. (whad-up-dough) is a colloquial greeting for "what's up though?", "hello", "what's up?" "Peace!", "hey!".

Through relaxed speech methods, this terminology originated in the streets of Detroit circa late 70's, early 80's.

Whaddupdoe can also be used in both exclamatory and interrogative forms.

Let's create a scenario...
Person A- Whaddupdoe Cuzzo?!? (another formal Detroit greeting).

Person B and replies back by saying "Whaddupdoe?"

Whaddup I'm Jared I'm 19 and I never fucking learned how to read 

Whaddup I'm Jared I'm 19 and I never fucking learned how to read is a vine reference used by nostalgic people who miss vine
"Hey could you read page 21 for the class?"
"No I can not WHADDUP I'M JARED I'M 19 AND I NEVER FUCKING LEARNED HOW TO READ