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A modern butchering of the previously named "Sci-Fi Channel", which is about all things sci-fi.
Syfy by Noel Ratsu August 8, 2009
Related Words
1. Originating in Polish, meaning zits, cum or filth in the plural and syphilis in its singular form ("syf").

2. Slang term for syphilis, often used in a mocking or even affectionate fashion.

3. Name of a TV network that shows imagination-based programming to go with their illusionary ratings. Failing after a re-branding press release insulted its core audience.
1. Co to za syfy? (Eng.: What is this crap?)

2. Aww, man, you better wear some protection or you'll get the syfy.

3. There's never anything good on the Syfy.
Syfy by Cricket_B March 18, 2009
He got syfy on the downlow.
Syfy by Science Boy March 16, 2009
An abbreviation or slang term for syphilis.
"Yo, dude! Did you hear that Jo-Jo caught syfy from that crack ho?"
syfy by ZeroCorpse March 16, 2009

Syfy quality 

(of a film) low budget, filled with pointless gore, excessive use of CGI
Acronym for "Shut Your Fucking Vagina"

Replaced the acronym STFU "Shut The Fuck Up" by "the RAGE"
LnD....SYFV (SHUT YOUR FUCKING VAGINA)!
SYFV by Chris Stopher February 19, 2009