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Off The Tizzy 

From or off the top or start of any given situation, any.
We just started our bowling game and White Mike got a strike off the tizzy.

Yo dat nigga popped dem shots off the tizzy, not me.

Congress will present Bill#"1040 Fuck the People" off the tizzy tomorrow morning.

On The Tizz 

Don't worry bout Kenny, throwing his shit at the windows, he's on the tizz.

I don't understand social situations because, I'm on the tizz.

You can't balme me, I'm on the tizz
On The Tizz by WillBill92 January 28, 2019

touch of the tizzle

To touch someone with your penis and give them a touch of the tizzle
I gave her the touch of the tizzle treatment
touch of the tizzle by RIZ EM February 23, 2025

That tizzle off the hizzle foshizzle 

"That is off the hook for real" would be the literal meaning of the phrase. It means that something is extremely novel and interesting, and that you're dumb enough to think you sound cool adding "izzle" to the end of your words.
Dude A: Hey dude, have you seen Frank's new car?
Dude B: Why yes I have. That tizzle off the hizzle foshizzle.
Dude A: WTF?!?!?!

the big nep tizzo' 

that cat is the big nep tizzo'
the big nep tizzo' by Harriet October 21, 2003