to be suffering from the unpleasant physical effects following the heavy use of drugs (with or without the use of alcohol), particulary drugs that deprive the user of sleep
When after continuous drug use, a user feels like they're not high despite being heavily impaired, resulting in continued heavy drug dosing. Easily observed by the impairment, physical deterioration and continued dosing of the user.
Did you see Erika? She's so strung out, her cheekbones could cut glass. She had me over, 'cause she couldn't step away from her pipe for more thana few minutes.