A phrase that is used when something completely upsetting, shocking, and mind-numbing occurs that questions the meaning of your existence and the existence of everything else.
Can also be used when you are speechless and there are no words to describe your thoughts.
Friend 1: She applied to 18 schools and she didn't get into ANY. And she has a 95 average.
You're at school and Colin walks up to the boys with an utter bouffant on his head. Michael points towards the fez-cut on Colin's head and exclaims "What is your head, cunt?"