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A person who is completely High On Meth and is very annoying
Twacked by Talor the Fox August 4, 2021
To be methed out to the point where your tweaking to the extreme, and your thoughts are shooting randomly in every direction a d you make no sense.
Hey brother, put the straw down, your twacked the fuck out!!
Twacked by SinisterGrimm December 28, 2021
My homie nate is twacked out of his fucking mind
Twacked by Davoi June 15, 2022

twacked out 

when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
twacked out by The KKK December 21, 2004

twacked out 

When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understand what the fuck you're saying cuz you're talking 100mph you're so twacked out.

I was so twacked out I thought there were undercover narcotics agents in the van parked across the street.
twacked out by Bowl Roller August 23, 2010

twacked the fuck out 

when some one is either high on an upper drug such a speed or caffeine or is really delirious after staying up for a long time or a combination of the two
shit dat nigga is "twacked the fuck out" on shards