when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understandwhat the fuck you're saying cuz you're talking 100mph you're so twacked out.
I was so twacked out I thought there were undercover narcotics agents in the van parked across the street.
when some one is either high on an upper drug such a speed or caffeine or is really delirious after staying up for a long time or a combination of the two