Nope 

A response to something that you want no part of.

Guy: (plays a YouTube video only to realize a moment later that it's a gross medical documentary) Nope!

Nope by Ash-Greninja December 30, 2016

Nope 

The ultimate vocal response in Team Fortress 2, spoken by the Engineer. A single word so powerful that not even the greatest RAGE or trolling can counter its effects.

1)
Player A: We'd probably be winning if we didnt have 5 engies building shit at the spawn

Engineer: NOPE

2)
Disgruntled player A: RTV! NOMINATE! SCRAMBLE! This map sux111!! Youre all using HAX!!11!

Engineer: NOPE

Nope by Zeromus255 October 4, 2011

Nope 

-To deny your ability to perform physical activities
-to bail out
-to fail

Boy1:OK, Brady you can do this back flip!
Brady: Well, okay...Okay guys!
Boy2:DO IT BRADSTAAAAAAH!!!! I'm filming!!!
Brady: I can do it!
*halfway through back flip*
Nope!
*falls on neck*
All: *hysterical laughter*

Nope by 13333333337gangsta February 23, 2009

Nope 

The new generations response to drug use. NOPE to DOPE. Showing an attitude of being disgusted with dope does. It's owning better choices for yourself.

NOPE! Noway I would poison myself with drugs!

Nope by jesRika December 26, 2019

nope 

slang for "no"

After hearing him say sorry for being a lamer about screwing with my best friend and ditching her, I said, "NOPE, she's never gonna talk to you since you flat out rejected her AND stopped talking to her!"

nope by wiCkEd eEv January 23, 2003

Nope 

The most common response from women when a man asks for anal sex.

Man: Would you like to try something?
Woman: Sure. Sounds exciting.
Man: Can we try anal? I'll be gentle...
Woman: Nope.

Nope by Andy Mui November 6, 2011

Nope 

Not happening. Nah. No no. NOT going to happen. I SAID NO! Nope.

Nope, just not happening

Nope by Pieceofshit43 May 6, 2020