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shortened form for 'most definitely'
A: you gonna come out tonight?
B: oh mosdef!
mosdef by AznC June 18, 2003
Related Words

Mosdefosho 

Most definitely for sure, used to express excitement about something.
Kayla "dude we should totally go climb the cliffs out at high cliff!"
Andrea "mosdefosho!"
Mosdefosho by mr.histheshit June 15, 2011
It means 'most definately'
Q. "will you make it tonight? "
A. "mosdef "
mosdef by mitta lee-alle "hannah" August 11, 2010

mosdefleet 

To be "Most Definently Elite".
Used an an adjective.
see also "Defleet"
"That was a tight game, mosdefleet imo"
mosdefleet by Matthew P May 24, 2006