rue21 

a cool but not well known clothing store.

person #1:I have these pants from rue 21
person: What?

rue21 by clara December 23, 2004

Rue21 

A clothing store that offers both punk and prep clothing. This store is usually split up with one side having many punky, outrageous clothes with the other having many cute clothes and Ts with funny sayings, like the ones on Wet Seal.
Not well known, but a very good-quality store.
Not to be confused with Forever 21.

Someone: Hey, what does your shirt say?
Me: Best Friends Forever, and it has a pic of Peanut Butter and Jelly.
Someone: That's cute, where did you get it?
Me: Rue21.

Rue21 by Saffiie May 31, 2009

RU21 

a product originally developed by the KGB. Now marketed in the UK as a hangover cure

ma heid's spinnin' - where's my RU21?

RU21 by lingurgitator December 17, 2004