derpfist Share definition Flag a derpfist is a person who does something incredibly stupid.another way to say "retard" person 1: that guy left his wallet in his unlocked car! person2: what a derpfist. derpfist by thedo0d June 19, 2009 0 0 Get merch Get the derpfist mug. Buy Now — $32.95 See more merch