a tweaker is simply a weirdo, from that weird girl who stalks you, the weird witch lady who lives at number 3 to that crazy old guy with the massive beard who rides his bike around all day muttering. its useful to have in the vocab as it can be shouted with no risk of insult to the tweaker in question. by streachin the sylables it can be made into an almost bird like cry. if u like
"oh my god, this guy is a fucking stalker, what a tweaker"

"shit dude, did you see that matey wearin girls clothes, what a tweeker"

"whos that tweaker on a microscooter"
by purv of the gore April 26, 2007
1) A speed, or meth addict who has assumed the role of the drug, in other words, they lost their personality to the drug.
2) An ex- deadhead or hippie who has fried their brain and is now living in the small, paranoid world of warped memories of a mundane adolescence. They communicate by spreading urban legends as "amazing" inspirational stories that align with their perception of reality.
3) A stupid, spastic teen (or adult, but less common) that display ignorance and naivety with every action.
I was walking through the Haight the other day and was surrounded by tweakers.

I went to my high school reunion and the tweakers were still messed up in the head.
by stv October 05, 2004
Philadelphia's (Philly's) own slut.
The word "tweaker" is often used to describe a girl with sloppy, slut-like attributes, and is known for getting with a lot of guys. A tweak is a nicer way of calling a female a whore, and or slut, and a tweaker may get with more popular, or famous guys. The word "tweak" is also used and is just a shorter version of the word "tweaker".
Malik: Yo, did you see Vanessa with Jamal last night? Yeah, she was giving him head in the back of the party, and everyone saw...
Kyle: Yeah, I know, that girl is such a tweaker.
Malik: Smh what a tweak.
by Olive_Garden69 October 30, 2011
Someone who Messes around with more than one person.
Christina had sex 5 Guys Last Night. She is Such A Tweaker!
by Mizzjas1802 October 13, 2010
Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
by briight April 06, 2010
a female that is a whore or has multiple sex partners. Originated in Philly; used in Philly and parts of Delaware.
Jon-ayo she a tweaker. da whole crew hit dat!

Jay-yo why did u and yo girl break up? she was fine!
Jon-yeah she was fine but she was a tweaker
Jay-aw man!
by lilmamapullin April 01, 2010
A female who has sex with a whole lot of guys and has no care of doing so.
She was at my house yesterday and now she's with my homie, I told him she was a tweaker.
by Geminibul23 January 19, 2011
A word used popularly in Philadelphia, Pa to describe female dogs who get “smutted” around by a group of men. The men are either friends, cousins or even siblings maybe complete strangers but that's rare with Tweaks. Tweakers are often exposed on the Tweaker List page via Facebook. Tweakers are not aware that they’re tweakers, until they appear on the Tweaker List. However, 99.9% are still in denial after being featured on every list. You can always find a Tweaker on Broad & Olney, King of Prussia, and Franklin Mills. They're in there like swimwear.
Girl: I'm not a tweak, I'm 15 years old and I let 5 guys hit.
I only sucked 14 dicks this year. Yes, I'm on the tweaker page, but these girls just hating on me because I had sexual intercourse with their boyfriends.

Boy: Your the true definition of a tweaker.
by Never Lying September 13, 2010

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