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43.
tweak=freak out, jumpy, on edge.
Shell tweaked when Mike scared her.
by mike January 26, 2005
12 31
 
44.
A druggie, a not sane person, an idiot, a person who punishes another person unfairly
Student: *FART*
Teacher: Go to the office
Student: Thats not fair, you're a tweaker!
_______

Tommy: Hey, Joe, look at John today, he's like high or something!

Joe: Man, he must be a tweaker!

_________

Crazy guy: Look at the flying donuts!
Insane asylum guard: My god, he is crazy!
Insane asylum guard 2: Man, he's a tweaker!

by Nerfer9 April 27, 2009
1 22
 
45.
a person who has lost life. they say it can kill you the first time you try it...if it doesn't you will wish it had.
The most prettiest girl in school got caught up in tweak...she isnt so pretty now and she is really mean with big gashes in her face from picking at it and no eye brows cuz she must have got really bored and tweaked by herself...poor girl she will never be the same
by I dont care how they do it February 24, 2005
14 36
 
46.
A small, long and narrow screwdriver, usually plastic, commonly used for adjustments to sensitive electronic components (coils, potentiometers etc)
"Hey Lou, pass me the tweaker, I need to make an adjustment here"
by anon-e-mouse April 11, 2005
10 33
 
47.
A person that lives in a trailer park or some sort of really shit housing that is always high on some sort of drugs. the way notice them is the really grungy, high look
Dude wtf is up with all these damn tweakers here?!?
by cereal killas May 11, 2006
10 35
 
48.
someone that drinks too many monster or other energy drinks and eats too much sugar or both and become twacked the fuck out like they are on methamphetamine.
kid: look what i bought, 2 monsters and 2 packs of twinkies.
me: damn kid u such a tweaker getting hyped up on that sugar and caffeine.
kid: lol
by skaterjack October 05, 2006
8 37
 
49.
a tweaker is simply a weirdo, from that weird girl who stalks you, the weird witch lady who lives at number 3 to that crazy old guy with the massive beard who rides his bike around all day muttering. its useful to have in the vocab as it can be shouted with no risk of insult to the tweaker in question. by streachin the sylables it can be made into an almost bird like cry. if u like
tweeeeee-kaaaaaahh
"oh my god, this guy is a fucking stalker, what a tweaker"

"shit dude, did you see that matey wearin girls clothes, what a tweeker"

"whos that tweaker on a microscooter"
by purv of the gore April 26, 2007
5 36