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1.
when something thoroughly satisfies your needs or desires
i love getting As on my tests. that shit really tickles my pickle
by mc3yee November 17, 2010
 
2.
When one deems a phrase or event humorous, one would show appreciation for this using this phrase.
"Wow, what a great joke, it really tickles my pickles."
"Do you know what tickles my pickles? Awkward people."
by Pold June 03, 2008
 
3.
food for thought; thought-provoking phrases and sentences
What tickles my pickle is how I can see through that door from all the way over here, but when I get up close to it I can't see a damn thing through it!
by reecardoh March 08, 2011