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1.
d. another term for really high grade marijuana
Rico said "Its that shit bra"
by Old City May 21, 2006
 
2.
Any item or concept is capable of being 'that shit'. Roughly analogous to 'it' or simply 'that'. Also appears as 'this shit'.

Can also refer to reefer.
You gotta smoke that shit while it's fresh.
by zerfetzte April 25, 2011
 
3.
A term used when I caught something from someone else (S.T.D)
Shay: I need to go to the doctor
Niki: Why?
Shay: I need a check-up
Niki: You got that shit!!!
Shay: Bitch don't play
by OneAMillion July 06, 2005