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1. slays
How someone may respond when something outlandish or surprising is said.
"Omgah...that slays me!"
by MelissaDv Jun 24, 2005 add a video
2. slays
A girl who by virtue is open to fornicating with just about anybody.
"Man I really need to get laid tonight"

"I heard there was some slays over at 3rd street"

"Let us head there with haste!"
3. slays
just incredible amazement, so fucking fun
Me: You own a beer?
Dude: Ya
Me: That Slays me
Dude: You say slays too?
Me: Ya, its the best way to describe someone who owns a beer!
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