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1.
to mercilessly fuck, bone and or screw a shady/skanky girl
1) I would definately slay that chick!

2) I slayed the fuck out of that hoocker last night!

3) Slay that bitch!

4) Freddy is off slaying fat bitches...
by karmaster March 19, 2006
750 455
 
2.
killed it. succeeded in something amazing.
Miley's new album slayed
by tsant October 09, 2013
312 70
 
3.
To dip; to use chewing tobacco, also used as a noun to mean dip. commonly used to discretely suggest to another that the two should go to dip in the bathroom. The phrase "Slay all dayyyyy" is used by non dippers to ridicule the dippers because at one time the phrase was quite common in the dipping community and taken seriously. The word is still in use although a few teachers and administrators in the area have discovered the meaning rendering the term un-usable in their presence.
Harrison: hey man lets go slay a grizzly in the bathroom

Riv Dog: Slay all dayyyyyy

Teacher: I know what that means.

Harrison: shit
by IslayGrizzly December 27, 2011
170 106
 
4.
The act of having sexual encounters with someone.
I slayed the hell out of her last night!
by Stainer August 02, 2004
363 315
 
5.
To destroy someone. Mainly cretins.
#SlayTheCretins

or

"Damn what a fucking cretin, SLAY HIM!"

or

"U fkn cunT i slAy u"
by Psych0ticDreams September 01, 2012
91 52
 
6.
How someone may respond when something outlandish or surprising is said.
"Omgah...that slays me!"
by MelissaDv June 24, 2005
70 35
 
7.
To go out drinking and take home a sexual partner.
I'm going to slay Jed tonight, no matter what it takes.
by sailorcharlie June 28, 2012
72 54