Sort of like "you do you," but with a strong implication that you're talking out of your ass. Basically "you're an idiot and what you're saying is stupid, if you want to keep going I guess I won't stop you."
Bob: "The world is run by lizard people."

Sue: "There's no such thing as lizard people, but go off, I guess."
by Mai Ainsel July 1, 2020
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When someone is proven to be wrong/stupid/lying, but you'll entertain them anyway.
You know we didn't sleep together, but go off I guess.
by Scratch 'N Sniff Asshole March 4, 2021
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you say this when your friend says something that proves you were wrong, but you don't want to admit it.
Gasinah: The answer to the math problem is 26, your paper says the answer is 76. you are stupid.

Jaakawbie: go off i guess
by mckenzielovesgrapes March 16, 2019
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Similar to a book off, where someone would ignore the person sittting next to them by reading a book, but in this case the person would put their headphones in and listen to their i-Pod instead. This is usually done when the person sitting next to them is annoying them, etc.
Connor was annoying me on the bus, so i gave him the I-Off
by hozz12 April 23, 2009
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A threat aimed at someone who is touching you in an uncomfortable or aggravating way.
guy 1: Look, just cuz the hottest girl in school dumped you doesn't mean anything. *puts arm around guy 2*

pissed off guy 2: Take it off before I break it off.
by Keith Hutch. September 24, 2007
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It is said when one has taken a large burden off their shoulders, such as completing coursework, having sex, or having their braces taken off.
Woah, Anson, you look happy today.

Yeah mate, I got my braces off, din' I?
by Partisan Passers-By Proxy March 15, 2016
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To try to do more than you are able to do.
I think I bit off more than I could chew when I agreed to paint this house by myself.
by xulapa October 1, 2014
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