Main Guy 

1. In video gaming, an enemy seen at the climax of a particular section of the game. Also known as a boss.

2. In film, the lead actor.

Friend "Hey wow you finally beat that level!"

You "No I still have to fight the main guy!"

Friend "Hey, who was the main guy in True Romance?

You "That would be Christian Slater"

Main Guy by Jorseman December 19, 2011

main guy 

practically anyone as long as you're fine, play a sport, bash, or people just like you for no sensible reason.

hes a main guy

main guy by mattiastoilet October 4, 2020

Main Guy 

Gender neutral definition of anyone having the the lead on a job or project where the workflows are separated between people.

The lead actress of a movie.

Lead host of a podcast.

The foreman of a work crew.

Im the main guy, she's the other guy.

Main Guy by Jules Elysard September 8, 2022

mrs.mainguy 

A teacher that blames you for wasting your time but really its her, shes rude and cares about only herself. and she will always tell you how cold Winnipeg is and how she had it harder

mrs.mainguy is a douche

mrs.mainguy by meh711 April 28, 2017

mainguy 

A boss ass bitch. Probably related to an ael

Wow, such she is such a mainguy

mainguy by Gorgonzola21 June 11, 2020