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Irritable Male Syndrome 

Irritable Male Syndrome (IMS) is the male equivalent of the female hormone change during menstruation. Believe it or not but men's hormones change every month too, this results in mood swings similar to those women experience. Luckily it doesn't cause men to bleed through their pecker.
Michael is suffering from Irritable Male Syndrome a.k.a his man period.

Irritable Bitch Syndrome 

The persistently inflammatory condition of a bitchy person, resulting in poor absorption of positive experiences while they express frequent yet pointless bitchiness. Habitual of certain men and women.
The beautiful, sunny day at the pricey amusement park was a nightmare with her Irritable Bitch Syndrome flaring up every ten minutes.
A state of being at which you are ready to punch the next person who fucks with you in the face.
Person 1: Bitch don't fuck with me right now, I'm so irritated.

Person 2: Those are women's jeans.
Person 1: Square up bud.
Irritated by Anon.myous November 8, 2016

Irritate 

1.to make one angry specialy by bitching and not Shuting the fuck up.
2. to be made uncomfrotable becuase of a rash thats itchy because your dirty.
Example 1.
dude 1. wtf is wrong with jerry?
dude 2. he is angry cuase his boss irritated the fuck out of him earlier.
Example 2.
chick 1. like what are you doing?
Chick 2. i like have this rash thats irritating me and.
Chick 1. like ewwww you have aids.
Irritate by Sahara Desert December 21, 2008

Irritable Jowel Syndrome

A chronic disease suffered by a good friend of mine. Symptoms include yakking it up when he should be keeping his pie-hole shut.
Ken:Hey Norm, remember the time you, me & the 3 Mormon chicks....
Norm: Hey Ken, STFU! My wife's right here and doesn't need to hear about how I banged that Morman every day for 2 straight months in a row! You f*ing have irritable jowel syndrome, dude~~
Irritable Jowel Syndrome by Bangboy December 26, 2009
Stop irritating me with your drivel, and go find the crap yourself.
irritated by Saints October 13, 2003