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1.
Used to describe a handshake from a person who has malicious intentions, in regards to your future.
Fuck smiley glad hands
With hidden agendas
Fuck these dysfunctional,
Insecure actresses

- from "Aenima" by Tool
by Thug 4 L1f3 September 21, 2005
 
2.
To shake hands with superficial, overzealous sincerity.

The quintessential, and most repugnant, gladhand is done with both hands around the other person's right hand.
The casino owner went around gladhanding the high rollers, hoping they would feel comfortable enough to drop a few hundred thousand.
by scoter April 01, 2012
 
3.
Gladhands are coupling devices used to connect the service and emergency air lines from a truck or tractor ("semi") to a trailer.
The truck driver connected the air lines to the trailer by pressing the gladhands together and rotating one 90 degrees to secure the connection.
by brossow March 18, 2010
 
4.
Gladhanding is what a politician or other powerful or famous person does when he shakes the hands of people he would normally avoid like a gay man running from pox-infested pussy.

The term gladhanding implies some lack of sincerity.
Dole gladhanded his way to the podium but lost all his cred when he fell off the stage.
by El Harlo March 28, 2008
 
5.
1. The part of an air brake system used to hook the truck to the trailer.

2. The hand a wanker uses.
Trucker Bob connected the gladhands to the trailer, then used his gladhand to yank his crank.
by josjr June 28, 2007