Top Definition
the act of hooking up for the first time (see: prude). The term "depruded" is often used by teenagers and preteens in some parts of the country, who are currently attending junior high or high school. The term is most common in Philadelphia and New Jersey.
Girl 1: "Renee isn't a prude anymore."
Girl 2: "I know. Henry depruded her."
by lalalove<3 August 25, 2009
Making someone do something sexual for the first time.
Dude, John de-pruded that hoe
by mac dizzle shizzle January 29, 2009

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