if someone is a prude, that means they haven't made-out with anyone yet. to be depruded is to take that away. in other words, to make-out for the first time. this person doesn't have to be straight or gay.
He depruded her because he was a whore.
by babieeboox322 May 17, 2008
The act of introducing prudish people to different, fun, and often times risque activities, situations, and/or language.
Jimmy was a wholesome boy from Missouri, but that all changed when he moved to Vegas. He was quickly depruded by new friends and coworkers, starting with nooners.
by Vegas Vicki August 15, 2011