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1.
The expression of such utter distaste for a person or object that it calls for the personal denial of its worldly existance. Can be used to express disintrest, hatred, or something/someone that has gone out of style.
Torn jeans are so last season. They're dead to me.
by muchluv November 22, 2005
 
2.
A phrase used as a comeback to let someone know they're dead to you
Tom: I slept with your mom, Greg.
Greg: You're dead to me.
by Thomas Wight December 30, 2005