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Can’t have shit in Detroit 

Meaning everything gets stolen in Detroit
Friend 1:My house was stolen
Friend 2:Can’t have shit in Detroit

can't have a shit in detroit 

Feeling terrible while in Detroit. Pretty obvious
Man I can't have a shit in Detroit

Can't have nice things 

When a friend is the literal reason, in every scenario, as to why you can't have nice things. (Ex: always spilling beers, falling over things, breaking things, etc.)
God damnit, Deborah! You're the reason we can't have nice things!

Can't have that 

The phrase used to describe when you are unable or unwilling to accept something, usually a large issue on the person's behalf.
Person 1: Shit, I'm about to die! I can't have that!

Can't have shit in 

Can't have shit in is a phrase users say online, it has a US state after the "in" part (it varies with any state).

It originally started out after someone posted a picture of their house and their porch missing on Facebook captioning it with, "Opened the door 🚪 and fell I’m pissed 😤 Can’t have shit in Cincinnati mfs done stole my porch bra 😠". Someone then re-posted it and re-captioned it to ,"Someone stole my fucking porch . I opened my door an fell 🤦 ♂️ u can't have shit in Detroit". The "Can't have shit in" phrase spread like wildfire with it varying between US states/cities. It points to the fact that you can't have shit anywhere without some mf taking it even if it has the littlest value to it, it also points to the fact mfs will just steal the most obcure random thing.
Person 1: Nahhh bro mfs done took all the shingles off my roof
Person 2: Can't have shit in Detroit

This is why we can't have nice things 

No matter how nice of a thing you have, no matter how hard you may try, someone will always find a way to fuck it up.
Josh: Hey bro can I borrow your phone?
Me: I dunno man, I just bought this. I don't even have a case on it yet!
Josh: Chill dude, I ain't gonna break it. It'll just take a second..
Me: Okay...
Josh:*Immediately drops it on the ground, denting the corner*
Me: God damn it Josh, this is why we can't have nice things.