Big Ugly Fat Fuck, aka, that annoying guy who considers himself to be all that, but in reality said person is just a douche bag. The term is typically used in veiled sarcasm by everyone else around said person, since he is far too oblivious to the intended meaning.
Troy: "Hey Jerry, you're looking pretty B.U.F.F. there, you been working out?"

Jerry: "What? Nah, I'm just naturally this way."

Steve: (to Troy, after Jerry walks away) "Did you really mean that?"

Troy: "Yep, he really is a Big Ugly Fat Fuck"
by Erkadurka June 09, 2011
when someone is hot, fit, generally good looking.
DAMN, devon is buff!!!
by SeanLovesDevon April 15, 2006
a muffless muff
A Brazilian waxjob made her muff a buff.
by Moby Doug April 07, 2009
big ugly fat friend. Every group of friends usually has one.
"Why does Sally hang out with them?"
"I don't know man, she's such a B.U.F.F.
by bma1 October 05, 2007
Big Ugly Fat Fuck. The affectionate nickname pilots gave to the Boeing B-52 Stratofortress. Derived from its sheer size (159 feet long, 185 foot wingspan), and the fact that it is ungainly in appearance on the ramp, due to it's 8 engines and bicycle landing gear.
The B-52 "BUFF" is shown many times in the movie Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb, and flew the world's longest combat sortie in 1991 in support of Operation Desert Storm, launching AGM-86 cruise missiles against high priority Iraqi targets.
by Kiwi90 February 05, 2007
to suck dick; give head
Yo, she buffed me yesterday in the stairwell.
by quantyn January 24, 2007
Muscly or fit. When you've been working out and got well defined muscles you're looking buff.
Somebody: "Did you see The Who at Live Aid?"

Somebody else: "Yeah, Daltrey was looking quite buff!"
by Makeety Makondo July 23, 2006

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