Nate: Dude, bring me some TP.
Penguin: Well, how much do you need?
Nate: Are you serious? A fuck'n roll.
Penguin: We have to conserve. Al Gore, Remember.
Nate: Holy shit! I need at least three assloads, maybe four. So figure it out Penguin or I'll wipe my ass with your pillow.
An extremely large amount that is beyond any other word, and so one can only resort to using a profanity. The subject being described also usually annoys the hell out of you.
Michael: "Hey, so you wanna go grab some drinks tonight?"
Jerry: "Nah, man, I can't. I have a test tomorrow, and I need to catch up on, like,.... an assload of homework."