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2.
The act of completely demolishing a girl whom you have a sexual encounter with, where during she makes noises as if she is dying from your cock sword.
Sam, "Dude are you gonna have sex with lauren?"
Brandon, "Yeah I'm totally going to slay her"
by B. Lan the Man February 05, 2012
 
1.
The act of doing something of great skill... excludes anything in relation to shuffleboard, steel drum, golf... etc. In many ways, it is among the lines of the term "swag".
What are you gonna do if you don't make it big? Are you going To Slay the Heroin Pipe?
by waffle267 January 23, 2012