Syphilis Seth Share definition Flag A person with a virtual STD otherwise known as I never get off of Facebook Syndrome. My roommate is such a Syphilis Seth he never turns his stupid computer off. Syphilis Seth by $Dolla $ D. $ Milli.$ October 26, 2009 0 0 Get merch Get the Syphilis Seth mug. Buy Now — $32.95 See more merch