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1.
Originated in the small town of Norton, MA. This is a popularly used term when referencing a high. Is used as a way to express ones mind-state after alcohol or marijuana intake.
Wow i am "smurffed" right now!

I'm about to get "smurffed" in a bit.
by Collegekidd December 28, 2010
 
2.
the act of sexual congress between two smurfs
Took her in the parking lot. She smurffed me
by Speedy November 01, 2003
 
3.
to be in a state of immense intoxication due to the introduction of toxins to the body.
10 pints of wifebeater and I'm completly smurffed
by the one that got away November 04, 2003