A bizarre disorder where the owner of a car, often a Nissan, has a tendency to hug the dotted line of a divided highway, occasionally drifting into the other lane, other times making it almost impossible to pass the sufferer.
Dude 1: "Dude, that douche just spent half an hour practically riding the center line, and he just shifted lanes without signaling!"
Dude 2: "Textbook Nissan Disease"
Dude 2: "Textbook Nissan Disease"
by JawshBawkes February 6, 2011