Jesticular Cancer

Cancer of the sense of humor. The sense of humor dies and the afflicted loses all ability to be funny. The only possible cure is a strong, regular dosage of hilarium

Brad: Yo, you wanna go hang with Tom?
Frank: Dude, I know I'm a dick, but he's just no fun since he got his Jesticular Cancer.
Brad: We should really cheer him up, though.
Frank: Fine. But we're getting ice cream after.