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1. when a man has a horrible deformity causing him to be born with testicles in his rectum and to make matters worse those testicles develop cancer

2. something you accuse any guy of having for the sake of comedy or as a comeback
ex1: doctor: I'm sorry, Tim, your anal testicles aren't well.
Tim: What do you mean?
doctor: You have anal testicular cancer.
Tim: Noooo!

ex2: Steven: I slept with your mom last night.
Joe: What you have anal testicular cancer?
by xxXbloodXvomitXxx February 18, 2011