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1.
to perform the act of masturbation ie a wank
after watching 'zoey 101', mike went into the bathroom for a quick 5 knuckle shuffle
by big bobs basterd beans December 04, 2005
 
2.
to: shake hands with the devil
self pollute
self harm
choke the chicken
releive ones self
wank
Gill: whats wrong Bob? Do you want me to perform fellatio to you again?

Bob: Fuck no, ur teeth grind me bell like a cheese grater, u fukin whore, get out, il have a 5knuckle shuffle instead
by 7clayton7 July 24, 2005
 
3.
The person above me is a perverted dumbfuck sickos; Don't listen to him/her.

5 Knuckle Shuffle is one of WWE Smackdown! Superstar John Cena's signature moves. He does his "You Can't See Me" then runs to the ropes, bounces against them, brushes his soldier then jumps down and punches you right in the face.
Tazz: Ohhh there goes Cena with his "you can't see me!", Cole!

Cole: 5 KNUCKLE SHUFFLE! And the pin...!
by Cena pwnz August 02, 2004