a phrase Females use when their friend is venting or Stating facts about someone.
kayla: "Patrica always tryna take peoples man but she not even cute."
Sam:" GO off Sis"
by missingthehitormiss January 14, 2019
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Sort of like "you do you," but with a strong implication that you're talking out of your ass. Basically "you're an idiot and what you're saying is stupid, if you want to keep going I guess I won't stop you."
Bob: "The world is run by lizard people."

Sue: "There's no such thing as lizard people, but go off, I guess."
by Mai Ainsel July 1, 2020
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To degenerate cognitively, to be in the process of having a mental breakdown, the process of going crazy
Jeff: I can't believe what my pops says sometimes. It's like he's incapable of higher thought!

Julian: Yeah, I'd say your pops is going off the deep end LOL!
by paynasty23 September 12, 2010
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When someone is proven to be wrong/stupid/lying, but you'll entertain them anyway.
You know we didn't sleep together, but go off I guess.
by Scratch 'N Sniff Asshole March 4, 2021
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One of the most popular asked questions of the century. Usually followed by "I yoink it then my splurg go off?" Scientists have never been able to solve this compelling question.
Man: What's up big man
Khat: Ay, da gloop go off?

Man: what
Khat: I yoink it then my splurg go off?
by D'twamm May 11, 2021
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bringing a girl to orgasm so hard and fast she moans like a whale out of painful pleasure
she was down on all fours going off like a whale.
by assmaster May 23, 2004
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The phrase a basketball player says when they think their going to drop a lot of points in a game
Friend: "You guys got a game today?"
Basketball Player: "Yeah, I'm about to go off today."
by LitLitYah February 4, 2017
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