To dance in a particular way referencing Bobbie Shmurda's song "hot nigga".
by Bholmes_xo November 26, 2014
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When someone with a small ass try's twerking
Damn Mami that is some fine tweaking

You cant twerk but you can tweak tho
by Blood THORNE October 24, 2017
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To be high on methamphetamine. NOT hallucinates
He's so tweaked out.
by kush_ March 17, 2005
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Frantic and compuslive behaviour often associated with methamphetamine abuse (crank). People who regularly abuse crank may find themselves unable to stop a particular random activity like searching drawers, having sex, or putting things apart. This is called tweaking.
"Oh man last night was awesome, I was tweaking and fucked my girlfriend for 6 hours straight..."
by RoOophy July 8, 2004
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