To "kick it" and/or fuck.
I'm not going to score a home run with Liv, but I hope to make it to third with my friend Brandon getting an RBI.
by Max Davenport October 19, 2004
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A humorous addition to any sentence. First made appearance in Halo 3 2: Halo 4 The Movie (available at Newgrounds)
"I mean we're gonna HOME RUN for it!"

"Show yourself home run!"

"Sounds like a bunch of mumbo-jumbo to me, home run."

"Be well, be well... home... ruu..."
by Allen Johnson March 13, 2006
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When a male masturbates with his laptop on his stomach and when at orgasm, ejaculates semen over the laptop screen.
I came so much I hit a home run!
by col_wake_N_bake February 7, 2015
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When you let you significant other touch you on you 'bases' then after they get caught not playing fair. They Strike out and you never she them again.
Man, I cannot believe she made a Home Run with my cousin and my friend.
After I let her touch my bases.
by The Other Trooth June 26, 2014
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To Letting Loose Of The Varsity Swim Team!
Hey Man, I let the Varsity Swim team out last night with Siela!
by xXBlazerXx January 2, 2004
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When guys, or girls, brag about getting a lucky home run, they ain't talking about baseball. They're usually referring to how they ran through the bases on a one night stand; First base, Second base, Third base, Fourth base, and yeah, that's right, Fifth base, baby! ;)
Guy 1: Dude, i just ran a Lucky Home Run: on the first date!
Guy 2: Sweeeet!!
by ForgeousChic101 July 24, 2011
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An orgy, or any occasion where lots of sexual intercourse is being had.
Last night's home run derby really tired me out, that was a lot of scoring!
by rhank April 16, 2008
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