1. To make one feel sick or disgusted.
2. To squick over a bizarre and distasteful situation.
3. My friendBrad in a speedo. *mentally squicking right now*
ie. "Dumbledore, McGonnagall and the Giant Squid are having a threesome and Ron is getting it on videotape."
Disgusting, icky, weird, often referring to something that is squelchy - imagine poking a vat of goo, and the sound you will make is similar to "squick".
Commonly known as the after-effect to "Hoomah". Squickey is the sound that your newborn creates after being launched down the stairs. The sound is a high pitched, squeaky sound that irritates your ear drums very thoroughly.
After she yelled Hoomah, her newborn did a Squickey on the floor.