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1.
Slang for "no".
Nope, I'm not going.
by ka len March 24, 2003
 
2.
A phrase to say when a hat hovers above your head, and then your neck elongates to make up for this, thus placing your head inside the hat. Seen mainly in city workers, or other people with hard hats.
Engineer 1: Hey, did you hear about what happened to Jim at the site?

Engineer 2: No

Engineer 1: Did you know there's a hat above your head?

Engineer 2: nope
by Zomegad January 18, 2011
 
3.
The best response to anyone who is trying to argue with you or debate you.

The ultimate comeback; unbeatable.
Dude, this song is horrible. - Shane
Nope. - Scott
by Scooter May 28, 2006
 
4.
When playing a scary video game, to nope is to throw down the controller, turn off the console and TV, back away slowly, and change your now soiled undergarments.

Basically, to wimp out.
I noped so hard when I saw Pyramid Head in Silent Hill 2.
by Graphxxxxz July 16, 2011
 
5.
'no' or 'negative'. An emphatic form of 'no'. Implying that the speaker's answer will not be changing in the future. Seems to be used when the speaker has to say no repeatedly, perhaps tiring of using 'no' and 'nope'.
Are we there yet?

Nope.

Can I get a cell phone?

Nope.

Can I have a raise?

Nope.
by zoot suit July 28, 2009
 
6.
Nowhere On Planet Earth. A view that the project in question should not be built anywhere, a more extreme view than Not In My Back Yard NIMBY and less extreme than Build Absolutely Nothing Anywhere Near Anyone.
Harvey had a NOPE view of the nuclear power plant, believing that it should not be built anywhere.
by CableHills January 15, 2007
 
7.
The reaction you have when seeing a scary insect or animal, e.g. a large spider.
*needs to pee, goes into bathroom, sees 5 inch long spider on the toilet seat*
You: *backs away slowly* Nope Nope Nope Nope Nope...
by Spiderbro June 19, 2013