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In gay subcultural slang, this usually means willing to get into anything sexually, including unsafe (unprotected) anal intercourse. This code word is, however, not just limited to gay or bi discourse.

"Jon's Manhunt ad says 'he's totally uninhibited.' That kinda freaks me out."
by djeremy July 15, 2008
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Holy shaith, Dr. Discolunchbox!
"I tumbled into a wormhole which sucked me into a parallel universe where this definition for 'Uninhibited' controls the entire galaxy and eggs eat people."
by Bastardized Bottomburp October 21, 2003
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