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When a man dies as a result of doing something that is both stupid, and something one would normally associate with steretypical "dumb guy" activity.

"The actions of the nominees are so shortsighted, so counter to common sense, that they can only be explained by the apparent need to strut superior risk-taking capacity."
- from The Darwin Awards (first book)
A Houston man earned a succinct lesson in gun safety when he played Russian roulette with a .45-caliber semiautomatic pistol. Rashaad, nineteen, was visiting friends when he announced his intention to play the deadly game. He apparantly did not realize that a semiautomatic pistol, unlike a revolver, actually inserts a cartridge into the firing chamber when the gun is cocked. His chance of winning a round of Russian Roulette was zero, as he quickly discovered.

- Darwin Awards, page 192
by Ugliness Man July 01, 2004
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2
The irrational rage a man goes into after being denied or not participating in sexual relations after regularly getting some.
(2 weeks with out sex)
guy: ahhhhh! she is such a bitch.
friend: what the hell are you talking about.
guy: she can't do anything right
friend: you are being unreasonable... wait, how long since you two did the bad stuff?
guy: iono two weeks
friend: oh... looks like you got testosterone poisoning dude.
by sdfjklasdfkj August 15, 2008
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3
When a trans woman goes through male puberty and grows facial hair and her voice deepens, etc.
Erika, though she had boobs from taking estrogen and had had all hair facial hair lasered off, was still getting clocked because of her deep voice as a result testosterone poisoning.
by Natalia Boa Vista November 21, 2016
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